Left Ventricular Function in Chronic Fatigue Syndrome (CFS): Data From Nuclear Ventriculography Studies of Response to Exercise and Postural Stress
Arnold Peckerman, Rahul Chemitiganti, Caixia Zhao, Kristina Dahl,
Benjamin H. Natelson, Lionel Zuckier, Nasrin Ghesani, Samuel Wang, Karen
Quigley and S. Sultan Ahmed.
Although abnormalities to autonomic function, plasma volume, and circulation are being increasingly observed in people with ME/CFS, a new study - presented at the conference of the American Physiological Society (Experimental Biology) April, 2003 in San Diego, California - reports reduced cardiac function in some patients.
Arnold Peckerman, and colleagues at University of Medicine and Dentistry of New Jersey, Newark, NJ, and the VA Medical Center, East Orange, NJ, studied 16 CDC-1994 defined patients and 4 matched control subjects. The radioisotopic multiple gated acquisition (MUGA) blood pool method of ventriculography was used to perform a series of dynamic studies of the heart to assess myocardial function, including resting ejection fraction (EF). Subjects were studied under maximal exercise, and an "active postural change" since some patients report worsening of symptoms during standing.
Overall, during maximal exercise, EF declined in CFS patients but increased in controls, and decreases in EF tended to be greater in patients with more severe symptoms. The authors conclude that these results represent preliminary indications of "reduced cardiac function in some patients with CFS," and that "further studies capable of defining more precisely the causes of altered cardiac stress responses are required.
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